Carbon-11 acetate as a tracer of myocardial oxygen consumption

Authors
Klein, LJ Visser, FC Knaapen, P Peters, JH Teule, GJJ Visser, CA Lammertsma, AA
Citation
Lj. Klein et al., Carbon-11 acetate as a tracer of myocardial oxygen consumption, EUR J NUCL, 28(5), 2001, pp. 651-668
Citations number
103
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
ISSN journal
03406997 → ACNP
Volume
28
Issue
5
Year of publication
2001
Pages
651 - 668
Database
ISI
SICI code
0340-6997(200105)28:5<651:CAAATO>2.0.ZU;2-6
Abstract
Estimation of myocardial oxygen consumption (MVO2) and myocardial blood flo w (MBF) is important for the understanding of various (patho)physiological mechanisms and diseases. Clearance rates of carbon-11 labelled acetate, det ermined with positron emission tomography, allow estimation of MVO2 on a se gmental level and non-invasively. In addition, MBF can be determined from u ptake rates. In this review, the background to estimation of MVO2 and MBF i s discussed, as well as the currently available literature that has used C- 11-acetate to estimate MVO2 and MBF.