Solid-phase synthesis of substituted pyrazolones from polymer-bound beta-keto esters

Authors
Tietze, LF Evers, H Hippe, T Steinmetz, A Topken, E
Citation
Lf. Tietze et al., Solid-phase synthesis of substituted pyrazolones from polymer-bound beta-keto esters, EUR J ORG C, (9), 2001, pp. 1631-1634
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
9
Year of publication
2001
Pages
1631 - 1634
Database
ISI
SICI code
1434-193X(200105):9<1631:SSOSPF>2.0.ZU;2-9
Abstract
Polymer-bound acetoacetate 3 was gamma -mono- and gamma -dial-kylated, as w ell as a-monoalkylated, to give 6, 9, and 13, respectively. Treatment with hydrazine or substituted hydrazines followed by thermal or acidic cyclizing cleavage yielded the pyrazolones 17a-dd in a purity of > 90%.