A. Ravhon et al., Clinical experience with recombinant follicle-stimulating hormone (FSH) and urinary FSH: a retrospective case-controlled analysis, FERT STERIL, 75(5), 2001, pp. 920-925
Objective: To compare the efficacy and efficiency of recombinant FSH (rFSH)
and urinary FSH (uFSH).
Design: Retrospective case controlled analysis.
Setting: An assisted reproduction unit at a university center.
Patient(s): 1388 patients undergoing long protocol in vitro fertilization/e
mbryo transfer (IVF-ET) using buserelin acetate from day 2 of the cycle and
either rFSH (follitropin beta) (n = 694) or uFSH (n = 694) with equal numb
er of ampules started (rFSH: 50 IU, uFSH: 75 IU).
Intervention(s): Patients were included in the two groups of treatment afte
r matching for similarity in age and type of treatment (IVF or intracytopla
smic sperm injection).
Main Outcome Measure(s): Total dose of FSH. ovarian response, and IVF outco
me.
Result(s): Patients who received uFSH experienced a shorter period of stimu
lation, and a higher number of oocytes were collected. The total FSH used w
as lower in the rFSH group, and they required a lower FSH dose per oocyte r
etrieved. The implantation and pregnancy rates were similar between the uFS
H and rFSH groups. In both groups implantation and pregnancy rates were hig
her when intracytoplasmic sperm injection was performed as compared with IV
F.
Conclusion(s): The implantation and pregnancy rates are similar when either
rFSH or uFSH is used (when compared on an ampule-to-ampule basis, rFSH: 50
IU, and uFSH: 75 IU). However, a significantly lower total FSH dose was us
ed in the rFSH group with a lower FSH dose per oocyte collected. (Fertil St
eril(R) 2001;75: 920-5. (C)2001 by American Society for Reproductive Medici
ne.).