Actin is oxidized during myocardial ischemia

Authors
Powell, SR Gurzenda, EM Wahezi, SE
Citation
Sr. Powell et al., Actin is oxidized during myocardial ischemia, FREE RAD B, 30(10), 2001, pp. 1171-1176
Citations number
27
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FREE RADICAL BIOLOGY AND MEDICINE
ISSN journal
08915849 → ACNP
Volume
30
Issue
10
Year of publication
2001
Pages
1171 - 1176
Database
ISI
SICI code
0891-5849(20010515)30:10<1171:AIODMI>2.0.ZU;2-4
Abstract
Exposure of isolated rat hearts to 30 min global ischemia followed by 60 mi n reperfusion resulted in a significant 80% increase (p <.05) in actin cont ent of carbonyl groups, which was associated with significant depression (p <.05) of postischemic contractile function. This result supports the hypot hesis that one mechanism of postischemic contractile dysfunction may be oxi dation of contractile proteins. (C) 2001 Elsevier Science Inc.