Sarcoma in association with multimodality management of vulvar cancer: Twocase reports

Background. Radiation-induced or -associated sarcoma is a rare event which has been well described in the literature. However, this entity has been in frequently described in association with genital tract malignancies. To our knowledge it has never been described in association with the management o f vulvar cancer. Cases. Two different cases of sarcoma developing after primary management f or vulvar cancer are presented, the first being a case of angiosarcoma deve loping in the lower abdominal wall 36 months after initial therapy and the second a case of fibrosarcoma developing on the vulva 7 years after multimo dality treatment. Conclusion. Radiation-associated sarcoma after treatment for vulvar carcino ma is a rare event. A multimodality treatment of carcinoma of the vulva sho uld not be withheld because of fear of sarcomagenesis. (C) 2001 Academic Pr ess.