Cost effectiveness of ramipril treatment for cardiovascular risk reduction

Objective--To assess the cost effectiveness of ramipril treatment in patien ts at low, medium, and high risk of cardiovascular death. Design--Population based cost effectiveness analysis from the perspective o f the health care provider in the UK. Effectiveness was modelled using data from the HOPE (heart outcome prevention evaluation) trial. The life table method was used to predict mortality in a medium risk cohort, as in the HOP E trial (2.44% annual mortality), and in low and high risk groups (1% and 4 .5% annual mortality, respectively). Setting--UK population using 1998 government actuary department data. Main outcome measure--Cost per life year gained at five years and lifetime treatment with ramipril. Results--Cost effectiveness was pound 36 600, pound 13 600, and pound 4000 per life year gained at five years and pound 5300, pound 1900, and pound 10 0 per life year gained at 20 years (lifetime treatment) in low, medium, and high risk groups, respectively. Cost effectiveness at 20 years remained we ll below that of haemodialysis (pound 25 000 per life year gained) over a r ange of potential drug costs and savings. Treatment of the HOPE population would cost the UK National Health Service (NHS) an additional pound 360 mil lion but would prevent 12 000 deaths per annum. Conclusions-Ramipril is cost effective treatment for cardiovascular risk re duction in patients at medium, high, and low pretreatment risk, with a cost effectiveness comparable with the use of statins. Implementation of ramipr il treatment in a medium risk population would result in a major reduction in cardiovascular deaths but would increase annual NHS spending by pound 36 0 million.