Synthetic analogues of naturally occurring spider toxins: Synthesis of 2-(hydroxyphenyl)propanamides of spermidine and spermine

Authors
Popaj, K Guggisberg, A Hesse, M
Citation
K. Popaj et al., Synthetic analogues of naturally occurring spider toxins: Synthesis of 2-(hydroxyphenyl)propanamides of spermidine and spermine, HELV CHIM A, 84(4), 2001, pp. 797-816
Citations number
25
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
84
Issue
4
Year of publication
2001
Pages
797 - 816
Database
ISI
SICI code
0018-019X(2001)84:4<797:SAONOS>2.0.ZU;2-C
Abstract
In a study on structure-activity relationships of spicier toxins, six model compounds, namely the spermidine derivatives 6, 8, and 16 as well as the s permine derivatives 24, 27, and 32 were synthesized. The synthesis proceeds through stepwise construction of the polyamine backbone, including protect ion and deprotection of the amino functions. The differentiation of the der ivatives bq analytical and spectroscopic methods is discussed.