K. Popaj et al., Synthetic analogues of naturally occurring spider toxins: Synthesis of 2-(hydroxyphenyl)propanamides of spermidine and spermine, HELV CHIM A, 84(4), 2001, pp. 797-816
In a study on structure-activity relationships of spicier toxins, six model
compounds, namely the spermidine derivatives 6, 8, and 16 as well as the s
permine derivatives 24, 27, and 32 were synthesized. The synthesis proceeds
through stepwise construction of the polyamine backbone, including protect
ion and deprotection of the amino functions. The differentiation of the der
ivatives bq analytical and spectroscopic methods is discussed.