ELEVATED DOSES OF CARMUSTINE AND MITOMYCIN-C, WITH LONIDAMINE ENHANCEMENT AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN THE TREATMENT OF ADVANCED COLORECTAL-CANCER - RESULTS FROM A PILOT-STUDY

Authors
FRANCHI F SEMINARA P PISANELLI GC BONAIUTI VPG GIOVAGNORIO F GUALDI G
Citation
F. Franchi et al., ELEVATED DOSES OF CARMUSTINE AND MITOMYCIN-C, WITH LONIDAMINE ENHANCEMENT AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN THE TREATMENT OF ADVANCED COLORECTAL-CANCER - RESULTS FROM A PILOT-STUDY, European journal of cancer, 30A(10), 1994, pp. 1420-1423
Citations number
34
Categorie Soggetti
Oncology
Journal title
European journal of cancer → ACNP
ISSN journal
09598049
Volume
30A
Issue
10
Year of publication
1994
Pages
1420 - 1423
Database
ISI
SICI code
0959-8049(1994)30A:10<1420:EDOCAM>2.0.ZU;2-U
Abstract
10 patients with advanced colorectal cancer were treated with elevated doses of carmustine and mitomycin C. The regimen was potentiated by L onidamine and supported by autologous bone marrow transplantation. The results of this pilot study were encouraging, with a response rate of 50% and a significantly better survival for responders versus non-res ponders. No appreciable toxicity of the therapy was observed. This asp ect, together with the simplicity of the procedure, calls for further investigations to confirm the good therapeutic index of the treatment.