Protein interaction property similarity analysis

We describe how similarity indices may be applied to semiquantitatively com pare the molecular interaction fields, such as electrostatic and hydrophobi c potentials, oi proteins. We then review ways in which this approach has b een used to investigate protein interaction properties in diverse applicati ons ranging from in-depth comparison of pairs of proteins to large-scale an alysis of hundreds of modeled protein structures. (C) 2001 John Wiley & Son s, Inc.