Six experiments were conducted to determine the true digestible valine requ
irement of 5- to 20-kg pigs. In Exp. 1, a valine-deficient diet for 5- to 1
0-kg pigs was developed and validated in terms of growth performance in res
ponse to supplemental L-valine. A different basal diet was validated for 10
- to 20-kg pigs in Exp. 2. Both diets were demonstrated to be deficient in
valine and to support performance equivalent to typical nursery diets when
fortified with L-valine. In Exp. 3, true ileal digestibility of valine in t
he two basal diets was determined in eight pigs fitted with a simple T-cann
ula at the terminal ileum. Another four pigs received an enzymatically hydr
olyzed casein-based diet to determine endogenous contributions to collected
ileal digesta. The two diets were found to have true valine digestibilitie
s of 82% (5- to 10-kg pigs) and 86% (10- to 20-kg pigs). In Exp. 4, 80 wean
ed pigs (5.8 kg) were offered the basal diet fortified with five incrementa
l doses (0.08%) of L-valine. Weight gain increased quadratically (P < 0.05)
with increasing levels of valine. Broken-line analysis revealed a true dig
estible valine requirement of 0.86 +/- 0.03%. In Exp. 5, the true digestibl
e valine requirement of 10- to 20-kg pigs was estimated with 120 pigs (10.9
kg) using the second basal diet fortified with six incremental doses (0.05
%) of L-valine. The data suggested a digestible valine requirement level of
about 0.775%, which was reevaluated in Exp. 6, wherein pigs did not respon
d to levels of digestible valine higher than 0.775%. In conclusion, require
ment estimates were 2.50 and 2.22 g of true digestible valine per megacalor
ie of ME for 5- to 10- and 10- to 20-kg pigs, respectively. These empirical
estimates are in close agreement with recent estimates of the National Res
earch Council Subcommittee on Swine Nutrition of 2.48 and 2.11 g of true di
gestible valine per megacalorie of ME, respectively.