Rearrangement of chromatin domains in cancer and development

Both the accomplishment of developmental programs and neoplastic transforma tion are linked to changes in the long-range organization of chromatin, in particular, DNA loop domains. The development of new methods that allow the study of interactions between the bases of DNA loops and the proteins of t he nuclear matrix will help our understanding of the molecular mechanisms i n such changes. These methods should also allow the establishment of a fing erprint "signature" for many cancers that may serve for diagnostic purposes , (C) 2001 Wiley-Liss, Inc.