An unusually aggressive case of endometriosis showing p53 expression

A 43 year old woman who underwent a hysterectomy and bilateral salpingo-oop horectomy for secondary dysmenorrhoea was found to have bilateral ovarian e ndometriosis. During the following four years she developed a series of tum ourlike vaginal masses, which were locally excised, a pelvic mass causing a cute large bowel obstruction, which necessitated an emergency Hartmann's pr ocedure, and a further pelvic mass causing hydronephrosis with a non-functi oning kidney. Pathological examination of all the resected specimens showed endometriosis with abundant stromal and glandular elements. Immunoreactivi ty for p53 protein was detected within endometriotic foci from the initial oophorectomy as well as the latest resection specimens. Immunostaining for p53 may help identify potentially aggressive cases of endometriosis for pro active treatment.