Measurement of homonuclear proton couplings from regular 2D COSY spectra

Authors
Delaglio, F Wu, ZR Bax, A
Citation
F. Delaglio et al., Measurement of homonuclear proton couplings from regular 2D COSY spectra, J MAGN RES, 149(2), 2001, pp. 276-281
Citations number
29
Categorie Soggetti
Chemistry & Analysis","Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MAGNETIC RESONANCE
ISSN journal
10907807 → ACNP
Volume
149
Issue
2
Year of publication
2001
Pages
276 - 281
Database
ISI
SICI code
1090-7807(200104)149:2<276:MOHPCF>2.0.ZU;2-B
Abstract
An interactive computer procedure is described which determines H-1-H-1 cou plings from fitting the cross-peak multiplets in regular phase-sensitive CO SY spectra. The robustness and simplicity of the method rely on the fact th at a given cross-peak intensity is not an independent variable in the fitti ng procedure, making it possible to measure couplings accurately even from individual cross peaks with unresolved multiplet structure.