Sesquiterpenes and monoterpenes from the bark of Inula macrophylla

Authors
Su, BN Takaishi, Y Yabuuchi, T Kusumi, T Tori, M Takaoka, S Honda, G Ito, M Takeda, Y Kodzhimatov, OK Ashurmetov, O
Citation
Bn. Su et al., Sesquiterpenes and monoterpenes from the bark of Inula macrophylla, J NAT PROD, 64(4), 2001, pp. 466-471
Citations number
28
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
4
Year of publication
2001
Pages
466 - 471
Database
ISI
SICI code
0163-3864(200104)64:4<466:SAMFTB>2.0.ZU;2-9
Abstract
Eleven new sesquiterpenes (1-11) and two thymol derivatives (12, 13), along with 12 known sesquiterpenes and monoterpenes, were isolated from the bark of Inula macrophylla. Their structures were determined on the basis of spe ctral evidence (especially by HREIMS and 2D NMR) as well as chemical transf ormations. The structure of macrophyllic acid A (1) was confirmed by X-ray analysis, and the absolute configuration of 1 was determined on the basis o f the appropriate chemical conversions and the application of a modified Mo sher's method.