14-Isovaleryloxy-O-methyl- 1,2-dehydrocacalol( 1) and cycloart-23-ene-3,25-
diol, beta -sitosterol, and stigmasterbl, along with five new cacalolides,
1-hydroxy-2-methoxy-1,2,3,4-dehydro-6-de (2), 1-hydroxy-2-methoxy-1,2,3,4-d
ehydrocacal (3), 1,2-dimethoxy-1,2,3,4-dehydro-6-dehydrox (4), 1,2-dimethox
y-1,2,3,4-dehydrocacalone (5), and 2-methoxy-O-methyl-l-oxo-2,3-dehydrocaca
(6), were isolated from Senecio madagascariensis collected from Colombia.
The structures of the new compounds were determined using one- and two-dime
nsional NMR techniques. In addition, the structure of 2 was corroborated by
derivatizations and single-crystal X-ray diffraction studies.