Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species

Authors
Killday, KB Yarwood, D Sills, MA Murphy, PT Hooper, JNA Wright, AE
Citation
Kb. Killday et al., Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species, J NAT PROD, 64(4), 2001, pp. 525-526
Citations number
15
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
4
Year of publication
2001
Pages
525 - 526
Database
ISI
SICI code
0163-3864(200104)64:4<525:MANCKI>2.0.ZU;2-N
Abstract
A new purine derivative microxine (1) was isolated from the Australian mari ne sponge Microxina sp. The compound was isolated via reversed-phase chroma tography and its structure determined spectroscopically. Microxine was foun d to weakly inhibit cdc2 kinase activity with an IC50 of 13 muM.