Two bioactive saponins from Albizia subdimidiata from the Suriname rainforest

Bioassay-guided fractionation of a methanol extract of Albizia subdimidiata using the engineered yeast strains 1138, 1140, 1353, and Sc7 of Saccharomy ces cerevisiae as the bioassay tool resulted in the isolation of the two ac tive saponins 1 and 2; one of these, albiziatrioside A (1), is described fo r the first time. The structures of 1 and 2 were established on the basis o f HRMS, 1D and 2D NMR spectral data. and GCMS analysis of the sugar units. Both isolated compounds showed significant cytotoxicity against the A2780 c ell line.