Anti-HIV prenylated flavonoids from Monotes africanus

Authors
Meragelman, KM McKee, TC Boyd, MR
Citation
Km. Meragelman et al., Anti-HIV prenylated flavonoids from Monotes africanus, J NAT PROD, 64(4), 2001, pp. 546-548
Citations number
21
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
4
Year of publication
2001
Pages
546 - 548
Database
ISI
SICI code
0163-3864(200104)64:4<546:APFFMA>2.0.ZU;2-4
Abstract
Six flavonoids, among them a new dihydroflavonol, 6,8-diprenylaromadendrin (1), and the flavonol. 6,8-diprenylkaempferol (3), have been isolated from the organic extract of Monotes africanus. The isolated compounds containing a 5,7-dihydroxy-6,8-diprenyl system in the A ring of the flavonoid (1, 3, and 6) exhibited HIV-inhibitory activity in the XTT-based, whole-cell scree n. In addition, several C-13 NMR assigments of lonchocarpol A (6) were corr ected.