Antibacterial diterpenes from the roots of Salvia blepharochlaena

Authors
Ulubelen, A Oksuz, S Topcu, G Goren, AC Voelter, W
Citation
A. Ulubelen et al., Antibacterial diterpenes from the roots of Salvia blepharochlaena, J NAT PROD, 64(4), 2001, pp. 549-551
Citations number
12
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
4
Year of publication
2001
Pages
549 - 551
Database
ISI
SICI code
0163-3864(200104)64:4<549:ADFTRO>2.0.ZU;2-M
Abstract
The roots of Salvia blepharochlaena have yielded two new diterpenoids, blep haein(l) and O-methylpisiferic acid methyl ester (2), together with eight k nown diterpenoids. The structures of the new compounds were established by spectroscopic analysis and by some chemical reactions. Potent antibacterial activity was exhibited by the known compounds horminone (9) and 7-acetylho rminone (10) against Staphylococcus aureus ATCC 6538 P, Staphylococcus epid ermidis ATCC 12226, and Bacillus subtilis ATCC 6633. Horminone was also fou nd to be active against Enterococcus faecalis ATCC 29212.