Jc. Paeng et al., Reproducibility of an automatic quantitation of regional myocardial wall motion and systolic thickening on gated Tc-99m-sestamibi myocardial SPECT, J NUCL MED, 42(5), 2001, pp. 695-700
Citations number
29
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
We investigated the reproducibility of an automatic quantitative algorithm
for measuring regional myocardial wall motion and systolic thickening. Meth
ods: Tc-99m-sestamibi gated myocardial SPECT with dipyridamole stress was p
erformed twice consecutively on 31 patients with known or suspected coronar
y artery disease, with the patients in the same position for each scan. Wit
h AutoQUANT software, segmental wall motion and systolic thickening were qu
antified automatically and expressed in millimeters and percentage increase
, respectively, for 20 segments. Afterward, the correlation and agreement b
etween repeated measurements were investigated, and the influences of wall
location, perfusion grade, and partitioning of the myocardium on reproducib
ility were evaluated by ANOVA and t testing. Results: High correlations (r
= 0.95 for wall motion and 0.88 for systolic thickening) and good agreement
s (weighted kappa = 0.81 and 0.71, respectively) were obtained from repeate
d measurements on consecutive gated SPECT. Changes in wall location and per
fusion grade did not cause significant differences between repeated measure
ments (P > 0.05 in ANOVA and t testing), but a change in partitioning did.
On Bland-Altman analysis, 2 SDs for repeated wall motion and for systolic t
hickening were 2.0 mm and 20%, respectively. Conclusion: The automatic quan
titative algorithm for myocardial SPECT provided by AutoQUANT software has
good reproducibility under diverse conditions. A change of motion > 2.0 mm
or a change of systolic thickening > 20% can be regarded as significant dur
ing a follow-up study using this software.