The role of a new noninvasive imaging technology in the diagnosis of anemia

Traditionally, numerical data regarding the status of a patient are a combi nation of measurements made at the point of care (POC) and those made in th e laboratory on specimens withdrawn from the patient. We report here on our experiences with a new method for a noninvasive determination of anemia, a s defined by blood hemoglobin (Hb) concentration. This method is based on a novel technology, orthogonal polarization spectral imaging, which provides high quality digitized images of the microcirculation using reflected ligh t. Measurements of Hb, based on the analysis of these images at the POC, we re found to compare favorably with results obtained with traditional labora tory methods. Additional advantages of these new POC technologies are that they will make possible completely new measurements that may have no direct analog with existing methods, For example, orthogonal polarization spectra l imaging can give feedback regarding microvascular density, which also may be reduced in anemic subjects. This information may give earlier and diffe rent insights regarding the patient status in nutritional deficiency anemia than an Hb concentration only. However, additional research will be requir ed to confirm the accuracy and utility of this measurement, especially in a dult and pediatric populations, where anemia is more commonly encountered. The ultimate success of POC testing will require collaboration between the attending health care professional, the laboratory and institutional manage ment to rapidly assimilate improved methodologies and new information to pr ovide benefits to the patient.