This article begins by reviewing the history of etiologic thinking in the f
ield of temporomandibular disorders (TMD). I conclude from this review that
not only are the old mechanistic etiologic concepts incorrect, but also th
at 2 of the most popular current concepts (biopsychosocial and multifactori
al) are seriously flawed. Therefore, what we really have at the individual
TMD patient level is nearly always an idiopathic situation-we simply do not
know enough, or cannot measure enough, or cannot precisely determine why e
ach patient has a TMD. In addition, we do not understand the host resistanc
e factors that ultimately determine why one person gets sick while another
does not. The issue of "why" (etiology) must be differentiated from the iss
ue of "how" (pathophysiology), both semantically and intellectually, to dis
cuss all of this properly. However, our current inability to precisely iden
tify etiologies in TMD patients does not prevent us from providing sensible
(and often successful) treatment for most of these patients. Many health c
onditions currently are treated by physicians and dentists with either inco
mplete or flawed understanding of their etiology, but the availability of e
mpirical data about treatment outcomes permits some level of appropriate ca
re to be given. Fortunately, a large number of comparative studies have bee
n done in the field of TMD therapy, providing us with a basis for selecting
initial therapies as well as for dealing with treatment failures. Even in
the absence of a perfect understanding of etiology, we still can provide go
od conservative care, and we should avoid aggressive and irreversible treat
ments, especially when they are based on flawed concepts of etiology. The a
rticle concludes by discussing current basic science research activities in
the field of TMD and orofacial pain. I propose that these ongoing studies
of the molecular and cellular mechanisms of joint disease, muscle pain, and
chronic pain are the most likely avenues to future progress in this field,
as specific countermeasures are developed to become the basis for more pre
cisely targeted therapies.