A novel and convenient method for synthesizing unsymmetrical N-benzyloxycarbonyl-protected 1-amino-1-arylalkylphosphonate mixed diesters

Authors
Xu, JX Fu, NY
Citation
Jx. Xu et Ny. Fu, A novel and convenient method for synthesizing unsymmetrical N-benzyloxycarbonyl-protected 1-amino-1-arylalkylphosphonate mixed diesters, J CHEM S P1, (10), 2001, pp. 1223-1226
Citations number
48
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
10
Year of publication
2001
Pages
1223 - 1226
Database
ISI
SICI code
1472-7781(2001):10<1223:ANACMF>2.0.ZU;2-V
Abstract
Unsymmetrical N-benzyloxycarbonyl-protected 1-amino-1-arylalkylphosphonate mixed diesters were synthesized using a one-pot reaction involving benzyl c arbamate, aromatic aldehydes and alkoxydichlorophosphine, followed by treat ment with alcohols in the presence of triethylamine. The reactions were fol lowed by P-31 NMR and a mechanism is proposed.