A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis

In this explorative study. interleukin-1 (IL-1) receptor antagonist (IL-1RA ; polymorphism of variable number of tandem repeats: VNTR), IL-1 alpha ( - 889), IL-1 beta (- 511) and IL-1 beta (+ 3953) polymorphisms were studied i n relation to susceptibility to and severity of multiple sclerosis (MS), in 93 MS patients and 400 normal controls. No associations were found for any polymorphisms, alone or in combination. However, in our MS cohort, females were found to be IL-1RA allele 2 carriers more frequently than males (33/4 9 vs. 16/44, p = 0.0028). Using a cohort of 109 controls, IL-1RA allele 2 c arriers were more frequently women with MS than control women (33/49 vs. 23 /43, odds ratio (OR)= 2.19, 95% confidence interval (CI) 1.02-3.72, p = 0.0 43, P-C = ns). The data suggest that the IL-1 cluster genes make no major c ontribution to MS, but the tentative association between IL-1RA allele 2 an d susceptibility of MS in women warrants further studies. (C) 2001 Elsevier Science B.V. All rights reserrved.