The recent description of exercise-induced intimal fibrosis affecting
mainly the iliac artery (and therefore usually described as external i
liac artery endofibrosis) has dramatically changed the diagnostic appr
oach of unexplained recurrent lower limb exercise pain, especially in
cyclists. Because arterial disease is often associated with the aftere
ffect of various concomitant musculotendinous lesions, several months
may pass before an arterial origin is suspected. The arterial origin o
f the pain must not be eliminated on normal ankle-to-arm index or norm
al Doppler velocity profiles at rest. Ultrasound examinations taken at
rest may show the lesions in 80% of endofibrotic patients and allow f
or the diagnosis of popliteal entrapment syndrome during dorsiflexion
of the foot. However, the hemodynamic consequences of a stenosis on th
e aortoiliofemoral axis can only be proved by measurement of the ankle
-to-arm index after exercise. A cutoff of this index <0.5 provides an
85% sensitivity in the detection of endofibrosis. Invasive investigati
ons (arteriography or angioscopy) will confirm the diagnosis before su
rgery is discussed. Although long-term results in endofibrosis are unk
nown, most of the surgically treated patients return to competition.