Ro. Macedo et Tg. Do Nascimento, Thermal characterization of lapachol by means of TG and DSC coupled to a photovisual system, J THERM ANA, 64(2), 2001, pp. 751-756
Thermal characterization is proposed as analytical methodology for the puri
ty assay of lapachol, and for determination of the quality parameters of ca
psules containing this molecule. The TG data revealed that lapachol is more
stable in the presence of adjuvants, showing the good quality of the formu
lation. The kinetic parameters obtained were lower for lapachol drug than f
or the formulated lapachol. The DSC data demonstrated good compatibility be
tween lapachol drug and the adjuvant in the formulated lapachol, and did no
t reveal impurities such as secondary products of the isolation and recryst
allization processes. The data were confirmed by the DSC-photovisual findin
gs.