Determination of essential amino acids involved in the CD4-independent tropism of the X4 human immunodeficiency virus type 1 m7NDK isolate: Role of potential N glycosylations in the C2 and V3 regions of gp120

Authors
Dumonceaux, J Goujon, C Joliot, V Briand, P Hazan, U
Citation
J. Dumonceaux et al., Determination of essential amino acids involved in the CD4-independent tropism of the X4 human immunodeficiency virus type 1 m7NDK isolate: Role of potential N glycosylations in the C2 and V3 regions of gp120, J VIROLOGY, 75(11), 2001, pp. 5425-5428
Citations number
28
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
11
Year of publication
2001
Pages
5425 - 5428
Database
ISI
SICI code
0022-538X(200106)75:11<5425:DOEAAI>2.0.ZU;2-0
Abstract
Seven mutations in the C2, V3, and C3 regions of gp120 are implicated in th e tropism of the first CD4-independent human immunodeficiency virus type 1 isolate, m7NDK. Site-directed mutagenesis revealed that three amino acids a re essential to maintain this tropism, one in the C2 region and two in the V3 loop. Two mutations implied N glycosylation modifications.