Feline immunodeficiency virus cell entry

The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found t o utilize the chemokine receptor CXCR4, but not CCR5, as a cellular recepto r. Zidovudine blocked formation of late viral replication products most eff ectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by F IV.