A. Rueda et al., Secondary prophylactic C-CSF (filgrastim) administration in chemotherapy of stage I and II Hodgkin's lymphoma with ABVD, LEUK LYMPH, 41(3-4), 2001, pp. 353-358
The purpose of this study was to determine the effect of granulocyte colony
-stimulating factor (filgrastim. G-CSF) for maintenance of chemotherapy dos
e-intensity in patients with stage I or II Hodgkin`s lymphoma treated with
six cycles of doxorubicin, bleomycin, vinblastine. and dacarbazine (ABVD).
7Fifty-six patients with stage I or II Hodgkin's lymphoma treated with ABVD
were eligible For secondary prophylactic G-CSF administration because of n
eutropenia (absolute neutrophil count < 1 x 10(9)/L) causing treatment dela
y or febrile neutropenia. Patients received 300 mug (total dose) of G-CSF (
filgrastim) subcutaneously on days 3 to 7 and 17 to 21 of each cycle in ord
er to prevent dose reduction or delay in subsequent cycles of treatment con
tinuing the G-CSF until completion of chemotherapy. Results showed that 30
(54%) of the patients required the use of G-CSF, 26 (47%) during the first
or second cycle. After G-CSF administration delay in chemotherapy did not o
ccur in 25 patients, whereas: delays in the Fifth or sixth cycle occurred i
n four patients, Despite treatment with G-CSF, one patient had febrile neut
ropenia. Dose intensity greater than 90% of that planned was delivered to m
ore the 85% of patients.
In conclusion: Secondary prophylactic G-CSF administration was necessary in
more than half of patients with stage I or II Hodgkin's lymphoma during ch
emotherapy with 48VD. The use of G-CSF allowed maintenance of chemotherapy
schedule and dose intensity in the majority of patients.