Estimating distribution of the age of onset of detectable asymptomatic cancer

Authors
Parmigiani, G Skates, S
Citation
G. Parmigiani et S. Skates, Estimating distribution of the age of onset of detectable asymptomatic cancer, MATH COMP M, 33(12-13), 2001, pp. 1347-1360
Citations number
32
Categorie Soggetti
Engineering Mathematics
Journal title
MATHEMATICAL AND COMPUTER MODELLING
ISSN journal
08957177 → ACNP
Volume
33
Issue
12-13
Year of publication
2001
Pages
1347 - 1360
Database
ISI
SICI code
0895-7177(200106)33:12-13<1347:EDOTAO>2.0.ZU;2-A
Abstract
In this paper, we develop a model and a deconvolution technique to estimate tile distribution of the age of onset of detectable preclinical cancer, us ing incidence data and information about cancer growth rate. Our approach c onsiders tile effect of age on both the growth rate and competing causes of death. We illustrate our methodology using data on breast cancer, and disc uss implications for breast cancer screening. (C) 2001 Elsevier Science Ltd . All rights reserved.