Alternative approaches to genome mapping and sequencing

The main methods used for large-scale mapping of the human and other genome s are reviewed. These methods comprise two procedures of random mapping/seq uencing and an approach using linking and jumping libraries. Importantly, n o method used up to now has proved efficient in comparative genome analysis . A new method is presented basing on slalom libraries. These libraries pro vide 10-100 times higher efficiency and may be used For mapping and sequenc ing whole genomes by small research groups.