The GDNF family: From neurotrophic factors to oncogenesis

Authors
Poteryaev, DA Saarma, M
Citation
Da. Poteryaev et M. Saarma, The GDNF family: From neurotrophic factors to oncogenesis, MOL BIOL, 35(2), 2001, pp. 261-270
Citations number
94
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
35
Issue
2
Year of publication
2001
Pages
261 - 270
Database
ISI
SICI code
0026-8933(200103/04)35:2<261:TGFFNF>2.0.ZU;2-4
Abstract
The structure and ill vivo functions of the glial cell-derived neurotrophic factor (GDNF) family ligands (GFLs) and their high-affinity receptors are considered. These proteins play an important role in the development of the nervous system, morphogenesis of the kidneys, and regulation of spermatoge nesis. Tyrosine kinase Ret is a common receptor component for all GFLs. Its role in multiple endocrine neoplasia type 2 (MEN2) is discussed.