Arylamine N-acetyltransferase activities in human breast cancer tissues

Citation
Ys. Geylan et al., Arylamine N-acetyltransferase activities in human breast cancer tissues, NEOPLASMA, 48(2), 2001, pp. 108-111
Citations number
15
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
NEOPLASMA
ISSN journal
00282685 → ACNP
Volume
48
Issue
2
Year of publication
2001
Pages
108 - 111
Database
ISI
SICI code
0028-2685(2001)48:2<108:ANAIHB>2.0.ZU;2-S
Abstract
N-Acetyltransferase activities were determined in tumor (12 malignant and 6 benign) and control (non-cancerous) breast tissues from 18 female patients . The activities of matched 12 malignant tumor and control tissue cytosols showed 6 rapid, 4 intermediate and 2 slow acetylators based on p-aminobenzo ic acid (NAT1) and sulfamethazine (NAT2) as substrates, Compared to the act ivities of slow acetylators, the rapid acetylators exhibited mean apparent V-max values about 5- and 50-fold greater for p-aminobenzoic acid and sulfa methazine, respectively. No correlation was observed between the blood and breast tissue N-acetyltransferase (NAT1 and NAT2) activities. When the mean apparent N-acetyltransferase activities of the malignant and benign breast tumor tissues were compared, the results showed an increased activity for both p-aminobenzoic acid (PABA) and sulfamethazine (SMZ) acetylation in the malignant tissues compared to benign ones, and also control tissues showed lower activities compared to tumor tissues. Moreover, the mean NAT2 activi ty was about 2-fold greater in the malignant tissues when compared to NAT1 activity.