Location and incidence of chromosome and chromatid breaks in patients withHodgkin's disease or testicular tumors

In 90 patients aged 17 to 35 who suffered from Hodgkin's disease (HD) or ha d testicular tumors (TT), the location of chromosome and chromatid breaks o n individual chromosome segments was reviewed using an adapted Funes-Cravio to scheme, in addition to examining the percentage of structural chromosoma l aberrations. On the basis of an analysis of 1121 breaks in patients with HD or Tf, the r esults were presented graphically as multiples of the expected number of br eaks for the normal population. Before the beginning of treatment, the numb er of structural chromosomal aberrations (SCA) in patients with TT or HD wa s equal to that in a control group of subjects with malignant diseases. Thi s, however, does not apply to the location of chromosome and chromatid brea ks. In patients with HD, the dominant unstable sites are located on group A(2) chromosomes, segments 2 and 5, and on group B chromosomes, segment 5. In pa tients with TT, the number of chromosome and chromatid breaks is also incre ased on group A(2) chromosomes, segments 2 and 5, and in addition, also on group B chromosomes, segment 4.