Oral recurrent human herpes virus infection and bone marrow transplantation survival

Objective. This study was conducted to compare the survival rates of bone m arrow transplantation (BMT) patients who were affected with the survival ra tes of those who were not affected by oral recrudescent human herpes virus- 1 infection (HHV-1) alter transplantation. Study design. Fifty-two consecutive patients who underwent BMT were include d in the study. The time of death after BMT was displayed, by means of the Kaplan-Meier method, for the following parameters: age and gender of the pa tient donor gender, primary disease, stem cells, conditioning regimen, plat elet number after day 100, acute and chronic graft-versus-host disease, ora l recurrent HHV-1 infection post-BMT, oral lichenoid lesions of graft-versu s-host disease, graft-versus-host disease at the salivary glands, parentera l nutrition, and oral mucositis. The data were initially analyzed by means of the log-rank test and then included in the Cox proportional hazards mode l. Results. The multivariate analysis demonstrated a significance of 5% for on ly the platelet numbers and oral recurrent HHV-1 infection. Conclusion. The present study provides evidence that platelet numbers below 100,000 cells/mm(3) after day 100 and oral recurrent HHV-1 infection are i ndependent negative prognostic variables in BMT patients' 24-month survival rates.