Solid phase synthesis of carbocyclic L-2 '-deoxynucleosides

Authors
Choo, H Chong, YH Chu, CK
Citation
H. Choo et al., Solid phase synthesis of carbocyclic L-2 '-deoxynucleosides, ORG LETT, 3(10), 2001, pp. 1471-1473
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
10
Year of publication
2001
Pages
1471 - 1473
Database
ISI
SICI code
1523-7060(20010517)3:10<1471:SPSOCL>2.0.ZU;2-Z
Abstract
[GRAPHICS] Carbocyclic L-2 ' deoxynucleosides 17 were synthesized on solid phase in fo ur steps from the appropriately protected intermedate 11, The Mitsunobu rea ction was used as a condensation method between the carbocyclic moiety and heterocyclic bases. The regioselectivity of the carbocyclic nucleosides was compared between the solid and solution phase syntheses.