Model systems for flavoenzyme activity. Control of flavin recognition via specific electrostatic interactions

Authors
Goodman, AJ Breinlinger, EC McIntosh, CM Grimaldi, LN Rotello, VM
Citation
Aj. Goodman et al., Model systems for flavoenzyme activity. Control of flavin recognition via specific electrostatic interactions, ORG LETT, 3(10), 2001, pp. 1531-1534
Citations number
30
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
10
Year of publication
2001
Pages
1531 - 1534
Database
ISI
SICI code
1523-7060(20010517)3:10<1531:MSFFAC>2.0.ZU;2-1
Abstract
A model system has been used to study the interactions of dipole containing aromatic systems with oxidized and reduced flavin, Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin gues t.