Vibrio cholerae is an uncommon cause of cellulitis in Australia. Most repor
ted cases worldwide have involved marine or brackish water contact. A recog
nized risk factor for acquiring this infection is chronic liver disease sec
ondary to hepatitis B, We describe a case of extensive facial cellulitis ca
used by Vibrio cholerae non-Ol, non-O139, in an 11-year-old indigenous girl
from North Queensland, Australia, who was hepatitis B surface antigen-nega
tive. Treatment consisted of extensive debridement, antibiotics, hyperbaric
oxygen and facial reconstructive surgery. Early microbiologic diagnosis an
d a combined therapeutic approach are important in the management of this c
ondition.