Mycobacterium fortuitum-chelonae complex infection in a child with complete interleukin-12 receptor beta 1 deficiency

Authors
Aksu, G Tirpan, C Cavusoglu, C Soydan, S Altare, F Casanova, JL Kutukculer, N
Citation
G. Aksu et al., Mycobacterium fortuitum-chelonae complex infection in a child with complete interleukin-12 receptor beta 1 deficiency, PEDIAT INF, 20(5), 2001, pp. 551-553
Citations number
15
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
PEDIATRIC INFECTIOUS DISEASE JOURNAL
ISSN journal
08913668 → ACNP
Volume
20
Issue
5
Year of publication
2001
Pages
551 - 553
Database
ISI
SICI code
0891-3668(200105)20:5<551:MFCIIA>2.0.ZU;2-E
Abstract
A 10-year-old boy had chronic diarrhea, abdominal pain, severe weight loss and hepatomegaly; multiple enlarged pare-aortic and mesenteric lymph nodes. Mycobacterium fortuitum-chelonae complex was identified in the culture of the lymph nodes. Interleukin-12 receptor beta 1 expression could not be obs erved in phytohemagglutinin-driven T cell blasts. A homozygous missense int erleukin-12 receptor beta 1 mutation was found (R173P).