Possible antineoplastic agents, part 15: synthesis, biological activity and quantitative structure activity relationship of substituted-2(4 '-methoxybenzenesulphonamido) glutaric acid analogs against Ehrlich ascites carcinoma

Some substituted-2-(4'-methoxybenzenesulphonamido) glutaric acid analogs (5 a-m, 7a-d) have been synthesized and tested for their possible antineoplast ic activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice us ing tumour (ascitic fluid) weight as activity parameter. Some of these comp ounds possess encouraging antitumour activity. A QSAR study, performed by t he classical Hansch method, explains the significance of hydrophobic bindin g and electronic influence in the mechanism of antineoplastic action in thi s group of compounds.