Ec. Lai et Gm. Rubin, neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development, P NAS US, 98(10), 2001, pp. 5637-5642
Citations number
46
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
neuralized(neur) is a neurogenic mutant of Drosophila in which many signali
ng events mediated by the Notch (N) receptor are disrupted. Here, we analyz
e the role of neur during eye development. Neur is required in a cell-auton
omous fashion to restrict R8 and other photoreceptor fates and is involved
in lateral inhibition of interommatidial bristles but is not required for i
nduction of the cone cell fate. The latter contrasts with the absolute requ
irement for Suppressor of Hairless and the Enhancer of split-Complex for co
ne cell induction. Using gain-of-function experiments, we further demonstra
te that ectopic wild-type and truncated Neur proteins can interfere with mu
ltiple N-controlled aspects of eye development, including both neur-depende
nt and neur-independent processes.