Some newer aspects of organozirconium chemistry of relevance to organic synthesis. Zr-Catalyzed enantioselective carbometallation

Authors
Negishi, E
Citation
E. Negishi, Some newer aspects of organozirconium chemistry of relevance to organic synthesis. Zr-Catalyzed enantioselective carbometallation, PUR A CHEM, 73(2), 2001, pp. 239-242
Citations number
25
Categorie Soggetti
Chemistry
Journal title
PURE AND APPLIED CHEMISTRY
ISSN journal
00334545 → ACNP
Volume
73
Issue
2
Year of publication
2001
Pages
239 - 242
Database
ISI
SICI code
0033-4545(200102)73:2<239:SNAOOC>2.0.ZU;2-J
Abstract
The reaction of terminal alkenes with trialkylalanes in the presence of chi ral (NMI)(2)ZrCl2 has been shown to be 70-75% ee for methylalumination and 90-95% ee for ethyl- and higher alkylalumination. It must involve an acycli c bimetallic process. Its scope, limitations, and applications to some natu ral products syntheses are discussed.