Interplay of synthesis and mechanism in asymmetric homogeneous catalysis

Asymmetric homogeneous catalysis forms one of the main planks of modern org anic synthesis. It has developed rapidly and largely through the applicatio n of novel ligands, whose design is very much based on insight and intuitio n. At the same time, a better understanding of catalytic reaction mechanism s can contribute to further progress, since it can identify the intimate re lationship between ligand structure and successful applications. The presen tation will concentrate an the author's research with complexes of the late transition metals and include the search for superior methodologies in hyd roboration, as well as ventures into the chemistry of reactive intermediate s. The latter will be exemplified from work with rhodium and palladium cata lysts.