Cholesterol efflux capacity in vitro predicts the severity and extent of coronary artery disease in patients with and without type 2 diabetes

Objective-To investigate the relation between severity and extent of corona ry artery disease (CAD) and in vitro cholesterol efflux capacity. Design-This study consisted of 46 type 2 diabetic, and 42 nondiabetic men u ndergoing coronary angiography, Quantitative coronary angiography was used to estimate the severity, extent, and overall "atheroma burden" of CAD. The capacity of patient plasma to induce cholesterol efflux from cultured Fu5A H rat hepatoma cells was measured in vitro. Results-In the combined study population (n = 88), there was a significant inverse correlation between efflux and global atheroma burden (r = -0.23, p < 0.05). In the diabetic group, the global atheroma burden index was indep endently associated both with cholesterol efflux and with LpA-I levels. How ever, in the nondiabetic CAD group this association was lost when efflux an d LpA-I levels were included in the same model. Conclusion-The present study demonstrated that efflux capacity was inversel y associated with the severity and extent of CAD. In the diabetic group thi s association was independent of LpA-I levels, suggesting impaired antiathe rogenic potential of these particles in type 2 diabetic patients.