Isolation and structure elucidation of two novel deformylase inhibitors produced by Streptomyces sp.

Authors
Chu, M Mierzwa, R He, L Xu, L Gentile, F Terracciano, J Patel, M Miesel, L Bohanon, S Kravec, C Cramer, C Fischman, TO Hruza, A Ramanathan, L Shipkova, P Chan, TM
Citation
M. Chu et al., Isolation and structure elucidation of two novel deformylase inhibitors produced by Streptomyces sp., TETRAHEDR L, 42(21), 2001, pp. 3549-3551
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
21
Year of publication
2001
Pages
3549 - 3551
Database
ISI
SICI code
0040-4039(20010521)42:21<3549:IASEOT>2.0.ZU;2-H
Abstract
Sch 382582 (1) and Sch 382583 (2), two novel pseudopeptides. were isolated from fermentation broth of Streptomyces sp. as bacteria peptide defurmylase inhibitors. Structure elucidation of I and 2 was accomplished by extensive 2D NMR spectroscopic studies including NOESY, HMQC-TOCSY and HMBC experime nts, and the relative stereochemistry was determined by X-ray crystallograp hy. Both compounds displayed potent inhibitory activity against E. coli def ormylase. (C) 2001 Elsevier Science Ltd. Ail rights reserved.