Synthesis of novel dendrimers incorporating a dye into the core

Dendrimers 1a and 1b, with six and nine terminal tert-butyloxycarbonyl (t-B oc) protected amine groups, respectively, have been prepared by an efficien t divergent synthetic approach. These novel dendrimers contain a dye Red-1 incorporated into the core, which adds to them, in addition to their physic ochemical properties proper to dendrimers. an additional one that is the vi sibility perceptible to human eyes. This new property was particularly inte resting in relation to our research of new carriers for active entities and /or antibodies. (C) 2001 Elsevier Science Ltd. All rights reserved.