Structure and characterization of a micro flow system for the study of modulated concentrations

This article discusses a micro flow system that was constructed using the p rinted circuit board technique, and where fluid flow is by hydrostatic pres sure. A new approach in the biosensor field, modulation of analyte concentr ation, is investigated. The flow and distribution of analyte molecules are examined by observing the dispersion of the analyte molecules under the con dition of modulation of their concentration by alternate injection of analy te solution and pure water. A theoretical model for the description of a se quence of dye packages in a micro channel under laminar flow conditions is compared with the experimental data. (C)2001 Elsevier Science B.V. All righ ts reserved.