Continuous recycling: a mechanism for modulatory signal transduction

Authors
Freeman, BC Yamamoto, KR
Citation
Bc. Freeman et Kr. Yamamoto, Continuous recycling: a mechanism for modulatory signal transduction, TRENDS BIOC, 26(5), 2001, pp. 285-290
Citations number
48
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
26
Issue
5
Year of publication
2001
Pages
285 - 290
Database
ISI
SICI code
0968-0004(200105)26:5<285:CRAMFM>2.0.ZU;2-J
Abstract
Modulatory signal transduction commonly requires efficient 'on demand' asse mbly of specific multicomponent cellular machines that convert signals to c ellular actions. This article suggests that for these signaling machines to detect and respond to fluctuations in signal strength, they must be contin uously disassembled in an energy-dependent process that probably involves m olecular chaperones.