JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A(2)beta

On the basis of significant sequence similarity, we have identified JmjC do mains in more than 100 eukaryotic and bacterial sequences,These include hum an hairless, mutated in individuals with alopecia universalis, retinoblasto ma-binding protein 2 and several putative chromatin-associated proteins. Jm jC domains are predicted to be metalloenzymes that adopt the cupin fold, an d are candidates for enzymes that regulate chromatin remodelling.