Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds revealed

Authors
Bujnicki, JM Radlinska, M Rychlewski, L
Citation
Jm. Bujnicki et al., Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds revealed, TRENDS BIOC, 26(1), 2001, pp. 9-11
Citations number
22
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
26
Issue
1
Year of publication
2001
Pages
9 - 11
Database
ISI
SICI code
0968-0004(200101)26:1<9:PEOTIR>2.0.ZU;2-U
Abstract
Using algorithms for protein sequence analysis we predict that some of the canonical type II and type IIS restriction enzymes have an active site with a substantially different architecture a nd fold from the "typical" PD-(D/ E)xK superfamily, These results suggest that they are related to nucleases from the HNH and GIY-YIG superfamilies.